Gloriam, D. E.: search on Z-Library

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1

Trends in GPCR drug discovery: new agents, targets and indications

Hauser, Alexander S., Attwood, Misty M., Rask-Andersen, Mathias, Schiöth, Helgi B., Gloriam, David E.

Journal:

Nature Reviews Drug Discovery

Year:

2017

Language:

english

File:

PDF, 1.47 MB

english, 2017

2

Total synthesis and structure–activity relationship studies of a series of selective G protein inhibitors

Xiong, Xiao-Feng, Zhang, Hang, Underwood, Christina R., Harpsøe, Kasper, Gardella, Thomas J., Wöldike, Mie F., Mannstadt, Michael, Gloriam, David E., Bräuner-Osborne, Hans, Strømgaard, Kristian

Journal:

Nature Chemistry

Year:

2016

Language:

english

File:

PDF, 2.68 MB

english, 2016

3

Proteomic applications of automated GPCR classification

Matthew N. Davies, David E. Gloriam, Andrew Secker, Alex A. Freitas, Miguel Mendao, Jon Timmis, Darren R. Flower

Journal:

Year:

2007

Language:

english

File:

PDF, 293 KB

english, 2007

4

Computer-Aided Discovery of Aromatic l -α-Amino Acids as Agonists of the Orphan G Protein-Coupled Receptor GPR139

Isberg, Vignir, Andersen, Kirsten B., Bisig, Christoph, Dietz, Gunnar P. H., Bräuner-Osborne, Hans, Gloriam, David E.

Journal:

Journal of Chemical Information and Modeling

Year:

2014

Language:

english

File:

PDF, 256 KB

english, 2014

5

Identification of a novel scaffold for a small molecule GPR139 receptor agonist

Nøhr, Anne Cathrine, Shehata, Mohamed A., Palmer, Daniel, Pokhrel, Rina, Vallianou, Maria, Foster, Simon R., Gentry, Patrick R., Gloriam, David E., Bräuner-Osborne, Hans

Journal:

Scientific Reports

Year:

2019

Language:

english

File:

PDF, 2.45 MB

english, 2019

6

The Contribution of Atom Accessibility to Site of Metabolism Models for Cytochromes P450

Rydberg, Patrik, Rostkowski, Michal, Gloriam, David E., Olsen, Lars

Journal:

Molecular Pharmaceutics

Year:

2013

Language:

english

File:

PDF, 1.21 MB

english, 2013

7

Bigger is better in virtual drug screens

Gloriam, David E.

Journal:

Year:

2019

Language:

english

File:

PDF, 273 KB

english, 2019

8

Novel Agonist Bioisosteres and Common Structure-Activity Relationships for The Orphan G Protein-Coupled Receptor GPR139

Shehata, Mohamed A., Nøhr, Anne C., Lissa, Delphine, Bisig, Christoph, Isberg, Vignir, Andersen, Kirsten B., Harpsøe, Kasper, Björkling, Fredrik, Bräuner-Osborne, Hans, Gloriam, David E.

Journal:

Scientific Reports

Year:

2016

Language:

english

File:

PDF, 2.16 MB

english, 2016

9

Structure–Activity Relationships and Identification of Optmized CC-Chemokine Receptor CCR1, 5, and 8 Metal-Ion Chelators

Chalikiopoulos, Alexander, Thiele, Stefanie, Malmgaard-Clausen, Mikkel, Rydberg, Patrik, Isberg, Vignir, Ulven, Trond, Frimurer, Thomas M., Rosenkilde, Mette M., Gloriam, David E.

Journal:

Journal of Chemical Information and Modeling

Year:

2013

Language:

english

File:

PDF, 3.67 MB

english, 2013

10

Lack of genomic imprinting in familial adenomatous polyposis

Petersen, GloriaM., Hwang, Shih-Jen, Giardiello, FrancisR., Krush, AnneJ.

Journal:

Year:

1993

Language:

english

File:

PDF, 169 KB

english, 1993

11

Editorial overview: New technologies: GPCR drug design and function—exploiting the current (of) structures

Tautermann, Christofer S, Gloriam, David E

Journal:

Current Opinion in Pharmacology

Year:

2016

Language:

english

File:

PDF, 222 KB

english, 2016

12

GPCRdb in 2018: adding GPCR structure models and ligands

Pándy-Szekeres, Gáspár, Munk, Christian, Tsonkov, Tsonko M, Mordalski, Stefan, Harpsøe, Kasper, Hauser, Alexander S, Bojarski, Andrzej J, Gloriam, David E

Journal:

Nucleic Acids Research

Year:

2018

Language:

english

File:

PDF, 2.47 MB

english, 2018

13

Pharmacology and function of the orphan GPR 139 G protein‐coupled receptor

Vedel, Line, Nøhr, Anne Cathrine, Gloriam, David E., Bräuner‐Osborne, Hans

Journal:

Basic & Clinical Pharmacology & Toxicology

Year:

2019

File:

PDF, 673 KB

2019

14

Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives

Robert Fredriksson, Pär J Höglund, David E.I Gloriam, Malin C Lagerström, Helgi B Schiöth

Journal:

Year:

2003

Language:

english

File:

PDF, 752 KB

english, 2003

15

GPCRdb: an information system for G protein-coupled receptors

Isberg, V., Mordalski, S., Munk, C., Rataj, K., Harpsoe, K., Hauser, A. S., Vroling, B., Bojarski, A. J., Vriend, G., Gloriam, D. E.

Journal:

Nucleic Acids Research

Year:

2015

Language:

english

File:

PDF, 2.59 MB

english, 2015

16

Identification of Histamine H3 Receptor Ligands Using a New Crystal Structure Fragment-based Method

Frandsen, Ida Osborn, Boesgaard, Michael W., Fidom, Kimberley, Hauser, Alexander S., Isberg, Vignir, Bräuner-Osborne, Hans, Wellendorph, Petrine, Gloriam, David E.

Journal:

Scientific Reports

Year:

2017

Language:

english

File:

PDF, 3.50 MB

english, 2017

17

Pharmacogenomics of GPCR Drug Targets

Hauser, Alexander S., Chavali, Sreenivas, Masuho, Ikuo, Jahn, Leonie J., Martemyanov, Kirill A., Gloriam, David E., Babu, M. Madan

Journal:

Year:

2017

Language:

english

File:

PDF, 8.56 MB

english, 2017

18

GPCRdb in 2021: integrating GPCR sequence, structure and function

Kooistra, Albert J, Mordalski, Stefan, PÃ¡ndy-Szekeres, GÃ¡spÃ¡r, Esguerra, Mauricio, Mamyrbekov, Alibek, Munk, Christian, KeserÅ±, GyÃ¶rgy M, Gloriam, DavidÂ E

Journal:

Nucleic Acids Research

Year:

2020

File:

PDF, 2.58 MB

2020

19

Structure-Activity Relationships of Constrained Phenylethylamine Ligands for the Serotonin 5-HT2 Receptors

Isberg, Vignir, Paine, James, Leth-Petersen, Sebastian, Kristensen, Jesper L., Gloriam, David E., Taylor, Paul

Journal:

Year:

2013

Language:

english

File:

PDF, 1.66 MB

english, 2013

20

There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini

Robert Fredriksson, David E.I. Gloriam, Pär J. Höglund, Malin C. Lagerström, Helgi B. Schiöth

Journal:

Biochemical and Biophysical Research Communications

Year:

2003

Language:

english

File:

PDF, 601 KB

english, 2003

21

Selectivity determinants of GPCR–G-protein binding

Flock, Tilman, Hauser, Alexander S., Lund, Nadia, Gloriam, David E., Balaji, Santhanam, Babu, M. Madan

Journal:

Year:

2017

Language:

english

File:

PDF, 11.82 MB

english, 2017

22

Structural Mapping of Adenosine Receptor Mutations: Ligand Binding and Signaling Mechanisms

Jespers, Willem, Schiedel, Anke C., Heitman, Laura H., Cooke, Robert M., Kleene, Lisa, van Westen, Gerard J.P., Gloriam, David E., Müller, Christa E., Sotelo, Eddy, Gutiérrez-de-Terán, Hugo

Journal:

Trends in Pharmacological Sciences

Year:

2017

Language:

english

File:

PDF, 4.27 MB

english, 2017

23

GPCRdb: an information system for G protein-coupled receptors

Isberg, Vignir, Mordalski, Stefan, Munk, Christian, Rataj, Krzysztof, Harpsøe, Kasper, Hauser, Alexander S., Vroling, Bas, Bojarski, Andrzej J., Vriend, Gert, Gloriam, David E.

Journal:

Nucleic Acids Research

Year:

2017

Language:

english

File:

PDF, 64 KB

english, 2017

24

Modulation in Selectivity and Allosteric Properties of Small-Molecule Ligands for CC-Chemokine Receptors

Thiele, Stefanie, Malmgaard-Clausen, Mikkel, Engel-Andreasen, Jens, Steen, Anne, Rummel, Pia C., Nielsen, Mads C., Gloriam, David E., Frimurer, Thomas M., Ulven, Trond, Rosenkilde, Mette M.

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 1.67 MB

english, 2012

25

Selective allosteric antagonists for the G protein-coupled receptor GPRC6A based on the 2-phenylindole privileged structure scaffold

Johansson, Henrik, Boesgaard, Michael Worch, Nørskov-Lauritsen, Lenea, Larsen, Inna, Kuhne, Sebastiaan, Gloriam, David E., Bräuner-Osborne, Hans, Sejer Pedersen, Daniel

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 919 KB

english, 2015

26

Minimum information about a protein affinity reagent (MIAPAR)

Bourbeillon, Julie, Orchard, Sandra, Benhar, Itai, Borrebaeck, Carl, de Daruvar, Antoine, Dübel, Stefan, Frank, Ronald, Gibson, Frank, Gloriam, David, Haslam, Niall

Journal:

Nature Biotechnology

Year:

2010

Language:

english

File:

PDF, 333 KB

english, 2010

27

High Species Variation within the Repertoire of Trace Amine Receptors

D E I GLORIAM, T K BJARNADÓTTIR, H B SCHIÖTH, R. FREDRIKSSON

Journal:

Annals of the New York Academy of Sciences

Year:

2005

Language:

english

File:

PDF, 1.53 MB

english, 2005

28

The human and mouse repertoire of the adhesion family of G-protein-coupled receptors

Thóra K. Bjarnadóttir, Robert Fredriksson, Pär J. Höglund, David E. Gloriam, Malin C. Lagerström, Helgi B. Schiöth

Journal:

Year:

2004

Language:

english

File:

PDF, 932 KB

english, 2004

29

Definition of the G Protein-Coupled Receptor Transmembrane Bundle Binding Pocket and Calculation of Receptor Similarities for Drug Design

Gloriam, David E., Foord, Steven M., Blaney, Frank E., Garland, Stephen L.

Journal:

Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 5.77 MB

english, 2009

30

Structural insight to mutation effects uncover a common allosteric site in class C GPCRs

Harpsøe, Kasper, Boesgaard, Michael W., Munk, Christian, Bräuner-Osborne, Hans, Gloriam, David E.

Journal:

Year:

2016

Language:

english

File:

PDF, 504 KB

english, 2016

31

Structure of the class D GPCR Ste2 dimer coupled to two G proteins

Velazhahan, Vaithish, Ma, Ning, PÃ¡ndy-Szekeres, GÃ¡spÃ¡r, Kooistra, Albert J., Lee, Yang, Gloriam, David E., Vaidehi, Nagarajan, Tate, Christopher G.

Journal:

Year:

2020

File:

PDF, 15.67 MB

2020

32

Design, Synthesis, and Pharmacological Characterization of N - and O -Substituted 5,6,7,8-Tetrahydro-4 H -isoxazolo[4,5- d ]azepin-3-ol Analogues: Novel 5-HT 2A /5-HT 2C Receptor Agonists with Pro-Cognitive Properties

Jensen, Anders A., Plath, Niels, Pedersen, Martin H. F., Isberg, Vignir, Krall, Jacob, Wellendorph, Petrine, Stensbøl, Tine B., Gloriam, David E., Krogsgaard-Larsen, Povl, Frølund, Bente

Journal:

Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 3.34 MB

english, 2013

33

Selective Negative Allosteric Modulation Of Metabotropic Glutamate Receptors – A Structural Perspective of Ligands and Mutants

Harpsøe, Kasper, Isberg, Vignir, Tehan, Benjamin G., Weiss, Dahlia, Arsova, Angela, Marshall, Fiona H., Bräuner-Osborne, Hans, Gloriam, David E.

Journal:

Scientific Reports

Year:

2015

Language:

english

File:

PDF, 1.80 MB

english, 2015

34

Pharmacology and function of the orphan GPR 139 G protein‐coupled receptor

Vedel, Line, Nøhr, Anne Cathrine, Gloriam, David E., Bräuner‐Osborne, Hans

Journal:

Basic & Clinical Pharmacology & Toxicology

Year:

2019

Language:

english

File:

PDF, 673 KB

english, 2019

35

Identification of the first surrogate agonists for the G protein-coupled receptor GPR132

Shehata, Mohamed A., Belcik Christensen, Hanna, Isberg, Vignir, Sejer Pedersen, Daniel, Bender, Andreas, Bräuner-Osborne, Hans, Gloriam, David E.

Journal:

Year:

2015

Language:

english

File:

PDF, 648 KB

english, 2015

36

Nine new human Rhodopsin family G-protein coupled receptors: identification, sequence characterisation and evolutionary relationship

David E.I. Gloriam, Helgi B. Schiöth, Robert Fredriksson

Journal:

Biochimica et Biophysica Acta (BBA) - General Subjects

Year:

2005

Language:

english

File:

PDF, 478 KB

english, 2005

37

Critical evaluation of the FANTOM3 non-coding RNA transcripts

Karl J.V. Nordström, Majd A.I. Mirza, Markus Sällman Almén, David E. Gloriam, Robert Fredriksson, Helgi B. Schiöth

Journal:

Year:

2009

Language:

english

File:

PDF, 323 KB

english, 2009

38

Editorial [Hot Topic: Methods for the Successful Application of Chemogenomics to GPCR Drug Design (Guest Editors: Stephen L. Garland & David E. Gloriam)]

L. Garland, Stephen, E. Gloriam, David

Journal:

Current Topics in Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 27 KB

english, 2011

39

The repertoire of trace amine G-protein-coupled receptors: large expansion in zebrafish

David E.I. Gloriam, Thóra K. Bjarnadóttir, Yi-Lin Yan, John H. Postlethwait, Helgi B. Schiöth, Robert Fredriksson

Journal:

Molecular Phylogenetics and Evolution

Year:

2005

Language:

english

File:

PDF, 1.24 MB

english, 2005

40

Chemogenomic Discovery of Allosteric Antagonists at the GPRC6A Receptor

David E. Gloriam, Petrine Wellendorph, Lars D. Johansen, Alex Rojas Bie Thomsen, Karina Phonekeo, Daniel Sejer Pedersen, Hans Bräuner-Osborne

Journal:

Chemistry & Biology

Year:

2011

Language:

english

File:

PDF, 1.04 MB

english, 2011

41

SMARTCyp: A 2D Method for Prediction of Cytochrome P450-Mediated Drug Metabolism

Rydberg, Patrik, Gloriam, David E., Zaretzki, Jed, Breneman, Curt, Olsen, Lars

Journal:

ACS Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 1.35 MB

english, 2010

42

Changes in driver cannabinoid prevalence in 12 U.S. states after implementing medical marijuana laws

Masten, Scott V., Guenzburger, Gloriam Vanine

Journal:

Journal of Safety Research

Year:

2014

Language:

english

File:

PDF, 1022 KB

english, 2014

43

Generic GPCR residue numbers – aligning topology maps while minding the gaps

Isberg, Vignir, de Graaf, Chris, Bortolato, Andrea, Cherezov, Vadim, Katritch, Vsevolod, Marshall, Fiona H., Mordalski, Stefan, Pin, Jean-Philippe, Stevens, Raymond C., Vriend, Gerrit, Gloriam, David

Journal:

Trends in Pharmacological Sciences

Year:

2015

Language:

english

File:

PDF, 2.88 MB

english, 2015

44

DUI Countermeasures: Differences between court jail sentences and jail time actually served and available alternative sanctions in select California counties

Guenzburger, Gloriam Vanine, Atkinson, Debra Barbiaux

Journal:

Journal of Safety Research

Year:

2014

Language:

english

File:

PDF, 586 KB

english, 2014

45

Applying label-free dynamic mass redistribution assay for studying endogenous FPR1 receptor signalling in human neutrophils

Christensen, Hanna B., Gloriam, David E., Pedersen, Daniel Sejer, Cowland, Jack B., Borregaard, Niels, Bräuner-Osborne, Hans

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2017

Language:

english

File:

PDF, 725 KB

english, 2017

46

Structure–Activity Relationships for Negative Allosteric mGluR5 Modulators

Dr. Birgitte H. Kaae, Dr. Kasper Harpsøe, Trine Kvist, Dr. Jesper M. Mathiesen, Christina Mølck, Dr. David Gloriam, Hermogenes N. Jimenez, Michelle A. Uberti, Søren M. Nielsen, Birgitte Nielsen, Prof.

Journal:

Year:

2012

Language:

english

File:

PDF, 866 KB

english, 2012

47

Comprehensive repertoire and phylogenetic analysis of the G protein-coupled receptors in human and mouse

Thóra K. Bjarnadóttir, David E. Gloriam, Sofia H. Hellstrand, Helena Kristiansson, Robert Fredriksson, Helgi B. Schiöth

Journal:

Year:

2006

Language:

english

File:

PDF, 692 KB

english, 2006

48

GPCRdb: the G protein-coupled receptor database - an introduction

Munk, C, Isberg, V, Mordalski, S, Harpsøe, K, Rataj, K, Hauser, A S, Kolb, P, Bojarski, A J, Vriend, G, Gloriam, D E

Journal:

British Journal of Pharmacology

Year:

2016

Language:

english

File:

PDF, 2.02 MB

english, 2016

49

Identification and characterization of small molecular NPR-B receptor antagonists

Andresen, Henriette, Moltzau, Lise Román, Fagerheim, Steffen, Gloriam, David, Bach, Trond, Levy, Finn Olav

Journal:

BMC Pharmacology and Toxicology

Year:

2015

Language:

english

File:

PDF, 206 KB

english, 2015

50

Rational design of a heterotrimeric G protein α subunit with artificial inhibitor sensitivity

Malfacini, Davide, Patt, Julian, Annala, Suvi, Harpsøe, Kasper, Eryilmaz, Funda, Reher, Raphael, Crüsemann, Max, Hanke, Wiebke, Zhang, Hang, Tietze, Daniel, Gloriam, David E, Bräuner-Osborne, Hans, St

Journal:

Journal of Biological Chemistry

Year:

2019

File:

PDF, 1.89 MB

2019

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